Melasma is a common acquired symmetric hypermelanosis characterized by irregular light to dark brown macules and patches on sunexposed areas of the skin. Its histopathologic characteristics are important for treatment. Melasma is characterized by
epidermal hyperpigmentation possibly by both the increased number of melanocytes and the increased function of melanogenic enzymes over the dermal solar changes.
Until now, curative measures are not available for melasma. Current therapies include topical agents (retinoic acid, hydroquinone, steroids), peeling (Combes solution, glycolic acid, TCA), and lasers(Co2, Erbium-Yag, Q-switched).
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